胎膜早破导致羊水菌群改变对妊娠结局的影响

Effect of amniotic fluid flora changes on pregnancy outcome caused by premature rupture of membranes

胎膜早破(premature rupture of membranes,PROM)是妊娠期常见并发症,发生率在20%以上。PROM常对母儿造成多方面的严重不良影响,尤其是新生儿感染性疾病的发生率显著增加。孕周越小、破膜时间越长对母儿结局的影响越大。传统观念认为胎儿在宫内发育的过程是无菌的,但随着研究方法的快速发展,针对于微生物的研究方法从传统的培养到现代分子生物学检测的进步,研究者已经认识到胎盘、羊水中存在微生物,并且可能对母儿产生不良影响。近年来已经认识到胎膜早破可以导致羊水菌群发生改变,而这种改变是否是导致不良妊娠结局的关键因素仍需进一步研究。

Premature rupture of membranes(PROM)is a common complication during pregnancy,with an incidence of more than 20%,and often causes serious adverse effects on mothers and infants in many aspects,especially the incidence of neonatal infectious diseases is significantly increased.The smaller the gestational age and the longer the time of rupture of the membrane,the greater the impact on the outcome of the mother and fetus.The traditional view is that the process of fetal development in uterus is aseptic,but with the rapid development of research methods,the research methods for microorganisms have changed from traditional culture to modern molecular biological detection.Researchers have recognized that there are microorganisms in placenta and amniotic fluid,which may affect mother and fetus.In recent years,it has been recognized that premature rupture of membranes can lead to changes in amniotic fluid flora,and whether this change is a key factor leading to adverse pregnancy outcomes or not should be studied further.