下咽癌患者的临床特征及其与预后的关系

Clinical features of patients with hypopharyngeal carcinoma and their relationship with prognosis

目的探讨下咽癌患者的临床特征及其与患者预后的关系。方法分析48例下咽癌患者的临床特征、远期生存情况及预后情况,下咽癌手术患者预后的影响因素采用Logistic回归分析。结果48例下咽癌患者1、3、5年总生存率分别为89.58%、81.25%和72.92%,无复发生存率为85.42%、77.08%和66.67%。48例下咽癌患者随访5年,生存35例,死亡13例,单因素分析结果显示,不同吸烟指数、淋巴结转移情况、临床分期、T分期和治疗方式下咽癌患者5年生存率比较,差异均有统计学意义(P﹤0.05)。Logistic回归分析结果显示,吸烟指数≥200支/年、有淋巴结转移、临床分期为Ⅲ~Ⅳ期、T分期为T3~T4和治疗方式为单纯手术是影响下咽癌患者5年生存率的独立危险因素(P﹤0.05)。结论吸烟指数、淋巴结转移情况、临床分期、T分期以及治疗方式等与下咽癌患者的预后密切相关,可作为评估患者远期预后的依据。

Objective To investigate the clinical features of patients with hypopharyngeal carcinoma and their correlation with prognosis. Method The clinical characteristics, long-term survival and prognosis of 48 patients with hypopharyngeal cancer were analyzed. Logistic regression analysis was used to analyze the prognostic factors of patients with pharyngeal cancer surgery. Result The 1-, 3-, and 5-year overall survival(OS) of 48 patients with hypopharyngeal carcinoma were 89.58%, 81.25%, and 72.92%, respectively, and the recurrence-free survival(DFS) were 85.42%, 77.08%, and 66.67%. The total subjects with hypopharyngeal carcinoma were followed up for 5 years, 35 cases survived, 13 cases died. The results of univariate analysis indicated that the 5-year OS of hypopharyngeal carcinoma patients with different smoking index, lymph node metastasis, clinical stage, T stage and treatment regimen were discrepant with statistical significance(P<0.05). Logistic regression analysis showed that smoking index ≥200 cigarettes/year, lymph node metastasis,clinical staging of Ⅲ-Ⅳ, T staging of T3-T4, and simply surgical treatment were independent risk factors affecting the 5-year OS of hypopharyngeal cancer patients(P<0.05). Conclusion Smoking index, lymph node metastasis, clinical stage,T stage, and treatment are closely related to the prognosis of patients with hypopharyngeal cancer, and these indicators could be used as the evidence for evaluating the long-term survival of relevant patients.