胸腺细胞选择相关高迁移率族蛋白在蕈样肉芽肿患者中的表达情况及临床意义

Expression of thymocyte selection associated high mobility group box protein in patients with mycosis fungoides and its clinical significance

目的探讨胸腺细胞选择相关高迁移率族蛋白(TOX)在蕈样肉芽肿(MF)患者中的表达情况及临床意义。方法选择62例MF患者作为观察组,其中斑片期25例,斑块期24例,肿瘤期13例,同时选取30例良性炎症性皮肤病患者作为对照组。采用免疫组织化学染色法检测两组患者中TOX蛋白的表达情况,比较观察组和对照组患者中TOX蛋白的阳性表达率,比较斑片期、斑块期、肿瘤期MF患者中TOX蛋白的阳性表达率。结果观察组患者中TOX蛋白的阳性表达率为91.94%(57/62),明显高于对照组的30.00%(9/30),差异有统计学意义(P﹤0.01)。斑片期、斑块期、肿瘤期MF患者中TOX蛋白的阳性表达率分别为80.00%(20/25)、100%(24/24)、100%(13/13),差异有统计学意义(P﹤0.05);但两两比较,差异均无统计学意义(P﹥0.05)。结论TOX蛋白在MF患者中的表达水平较高,可能在疾病进展中具有一定作用,值得进一步研究。

Objective To investigate the expression of thymocyte selection associated high mobility group box protein(TOX)in patients with mycosis fungoides(MF)and its clinical significance.Method A total of 62 cases with MF were selected as the observation group,including 25 cases in the patch stage,24 cases in the plaque stage,13 cases in the tumor stage,and 30 patients with benign inflammatory skin diseases were selected as the control group.Immunohistochemical staining was used to detect the expression of TOX in the two groups.The positive rate of TOX in the observation group and the control group was compared,and the positive rate was also compared between different stages in the observation group.Result The positive rate of TOX in the observation group was 91.94%(57/62),which was significantly higher than 30.00%(9/30)in the control group,and the difference was statistically significant(P<0.01).The positive rate of TOX in MF patients in the patch stage,plaque stage and tumor stage were 80.00%(20/25),100%(24/24),and 100%(13/13),respectively,and they were statistically significant different(P<0.05).However,no statistically significant differences were found when compared between pairs(P>0.05).Conclusion TOX is highly expressed in MF patients and may make sense in the development of disease,which is worthy of further study.