摘要
G蛋白偶联受体(G protein coupled receptors,GPCRs)是一类广泛存在于细胞表面具有7个跨膜螺旋的膜蛋白,是人体中种类和数量最多的膜受体蛋白家族.由于GPCR参与了生物体内的众多细胞信号转导和生理反应过程,所以GPCR已成为治疗多种疾病的重要药物靶点,其立体结构的解析对于相关药物设计具有非常重要的意义.通过查询相关学术期刊网上与GPCR相关文献并进行解析,简要综述了GPCR的结构、磷酸化、异源二聚化,GPCR与疾病及其靶向药物,然后对GPCR未来的相关研究进行展望.
G protein coupled receptors(GPCRs)are a kind of membrane proteins which are widely distributed on the cell surface and have seven transmembrane helices.GPCRs are the largest family of membrane receptor proteins in human body.GPCR is involved in many cell signal transduction and physiological reaction processes,so it has become an important drug target for many diseases,and the analysis of its three-dimensional structure is of great significance for drug design.By consulting a large number of literatures related to GPCR on academic journal network,this paper briefly reviewed the structure of GPCR,phosphorylation and heterodimerization of GPCR,GPCR and disease,GPCR and its targeted drugs,and looked forward to the future research of GPCR.
作者
王靖
徐芳
杨孔
WANG Jing;XU Fang;YANG Kong(Institute of Food and Nutrition Development,Ministry of Agriculture,Beijing 100081,China;School of Life Science and Technology,Southwest Minzu University,Chengdu 610041,China;Institute of Qinghai-tibetan Plateau,Southwest Minzu University,Chengdu 610041,China)
出处
《西南民族大学学报（自然科学版）》
CAS
2020年第6期563-570,共8页
Journal of Southwest Minzu University(Natural Science Edition)
基金
国家科学技术部科技基础性工作专项重点项目资助(2014FY110100)
湖北省科技条件平台建设专项(2017BEC014)。
关键词
GPCR
晶体结构
异源二聚化
药物作用靶标
G protein-coupled receptor
crystal structure
heterodimerization
drug targe
