手性氨基酸酰胺催化剂的发现及研究进展

Discovery and Typical Advances of Chiral Amino Amide Catalysts

自从L-脯胺酰胺被发现能高效催化不对称aldol反应以来,手性氨基酸酰胺催化剂的设计及不对称催化研究一直受到关注。特别是"烯胺-双氢键"模型的提出为设计新型有机小分子催化剂提供了理论依据,使催化剂的结构设计趋于多样化。本文重点总结了含有单氢键给体、双氢键给体及多氢键给体的氨基酸酰胺催化的不对称催化反应,主要包括不对称直接aldol反应、Mannich反应、Michael加成反应、环加成反应、串联环化反应、Biginelli反应等方面的研究进展。

Since L-prolinamide was revealed to have high capacity to catalyze asymmetric aldol reaction,great advances have been made on the design of chiral amino amide catalysts and their applications in asymmetric catalysis.In particular,the"enamine-double hydrogen-bonding activation mode"has turned out to be a general concept for the proliferation of structurally diverse range of organocatalysts.This review mainly describes asymmetric reactions catalyzed by chiral amino amides containing single hydrogen-bonding donor,double hydrogen-bonding donors and multiple hydrogen-bonding donors,including enantioselective direct aldol reaction,Mannich reaction,Michael addition reaction,cycloaddition reaction,tandem cyclization reaction,Biginelli reaction and others.