邻菲罗啉类配体在铁系元素催化反应中的应用

Progresses of 1,10-Phenanthroline Type Ligands in Fe/Co/Ni Catalysis

邻菲罗啉是一类经典的双氮配体,可与多种过渡金属形成稳定的络合物,被广泛用于催化有机合成反应中。铁系元素(铁、钴、镍)具有自然丰度高、价格低廉、生物兼容性好、催化性能独特等优点,其络合物是理想的备选催化剂。近年来,邻菲罗啉类配体在铁系元素催化的有机反应中得到越来越多的应用,表现出独特的配体效应。在本文中,我们系统梳理了邻菲罗啉类配体在铁系元素催化有机反应中的应用研究进展,并对该领域的未来发展进行了展望。

1,10-Phenanthroline and its derivatives,classic bidentate N-donor ligands,can form stable complexes with a variety of transition metals and have been widely used as catalysts in various organic reactions.Ferritic elements(iron,cobalt,nickel)have the advantages of high natural abundance,low cost,low toxicity and unique catalytic performance.The complexes of 1,10-phenanthroline type ligands and ferritic elements are ideal alternative catalysts.In recent years,1,10-phenanthroline type ligands have been widely used in Fe/Co/Nicatalyzed organic reactions,especially in cross-coupling reactions,addition reactions,and redox reactions,showing unique ligand effects.More and more studies revealed that the rigid aromatic structure of 1,10-phenanthroline plays an important role in improving the stability of the catalyst,and the substituents of 1,10-phenanthroline have a significant impact on the activity and selectivity of corresponding catalyst.More interestingly,a few recent studies disclosed that 1,10-phenanthroline ligands might change the spin state and three-dimensional electronic structure of the Fe/Co/Ni catalysts,which accounts for their unique reactivity as well as selectivity.Although with the above-mentioned progresses,there are still several important challenges in this field,including the poor structural diversity of 1,10-phenanthroline type ligands and poor understanding of the electron effect of 1,10-phenanthroline ligands to corresponding metal catalysts.In this review,we summarized the applications of 1,10-phenanthroline ligands in Fe/Co/Ni-catalyzed organic reactions,and gave an outlook of this promising field.