妊娠剧吐患者甲状腺功能指标、甲状腺自身抗体的表达水平及其意义

Changes and Significance of Thyroid Function Indicators and Thyroid Autoantibodies in Patients with Hyperemesis Gravidarum

【目的】探讨妊娠剧吐患者甲状腺功能指标、甲状腺自身抗体的表达水平及意义。【方法】选取2015年1月至2018年12月在本院诊治的妊娠剧吐孕妇60例(观察组),同时选取正常孕妇60例(对照组),检测并比较两组血清游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺素(TSH)和甲状腺球蛋白抗体(TgAb)和甲状腺过氧化物酶抗体(TPOAb)阳性率。【结果】观察组FT3和FT4水平明蛊高于对照组(P<0.05),而TSH水平明显低于对照组(P<0.05);但两组TgAb、TPOAb阳性率比较差异无统计学意义(P>0.05);观察组妊娠剧吐评分>8分孕妇FT3和FT4水平明显高于评分<8分孕妇(P<0.05),而TSH水平明显低于评分<8分孕妇(P<0.05)。【结论】妊娘剧吐患者血清FT3和FT4明显升高,TSH明显降低,与病情可能有一定关系,而曱状腺自身抗体阳性率无明显变化。

【Objective】To investigate the changes and significance of thyroid function parameters and thyroid toantibodies in patients with hyperemesis gravidarum.【Methods】A total of 60 patients with hyperemesis gravidarum(the observation group)and 60 cases of normal pregnant women(the control group)were selected from January 2015 to December 2018 in our hospital.Serum free triiodothyronine(FT3),free thyroxine(FT4),thyrotropin(TSH),thyroglobulin antibody(TgAb)and thyroid peroxidase antibody(TPOAb)were detected in the two groups.【Results】The levels FT3 and PT4 in the observation group were(4.78±0.82)and(19.82±3.44)pmol/L,respectively,which were significantly higher than those of the control group(P<0.05),while the TSH was(0.69±0.21)mlU/L,which was significantly lower than that of the control group(P<0.05).There were no significant difference in the positive rates of TgAb and TPOAb between the observation group and the control group(P>0.05).In the observation group,FT3 and FT4 levels of parturients with hyperemesis gravidarum score were(5.02±0.91)pmol/L and(21.15±2.81)pmol/L,respectively,which were significantly higher than those of parturients with score<8(P<0.05),while TSH level was(0.61±0.19)mIU/L,which was significantly lower than those of parturients with score<8(P<0.05).【Conclusion】The serum levels of FT3 and FT4 in hyperemesis gravidarum patients are significantly increased and TSH is significantly decreased,which may be related to the condition of hyperemesis gravidarum,but the positive rate of thyroid autoantibody has no significant change.