结肠癌组织中MCL-1、NIBP表达情况及其与肿瘤进展的相关性

Relationship of MCL-1 and NIBP Expression in Colon Cancer Tissues with Tumor Progression

【目的】探讨结肠癌患者结肠癌组织中髓细胞白血病基因-1(MCL-1)、NIK-IKK结合蛋白(NIBP)表达情况及其与肿瘤进展的相关性。【方法】采用免疫组化染色方法检测获取的82例结肠癌术后癌组织、对应的癌旁组织中的MCL-1蛋白、NIBP蛋白表达水平;分析不同TNM分期、肿瘤分化程度、病灶大小等病理学参数与结肠癌组织中的MCL-1蛋白、NIBP蛋白的阳性表达率的相关性。【结果】结肠癌组织的MCL-1蛋白、NIBP蛋白阳性率分别为68.29%、60.98%,均显著高于癌旁组织的26.83%、20.73%,差异均有统计学意义(P<0.05)。不同肿瘤浸润深度、不同病理学分化程度、不同TNM分期、是否发生淋巴结转移的结肠癌组织中MCL-1蛋白、NIBP蛋白阳性率组间比较,差异均有统计学意义(P<0.05)。【结论】结肠癌组织中MCL-1蛋白、NffiP蛋白表达较癌旁&织显著增高,这可能与结肠癌的进展有一定的相关性。

【Objective】To investigate relationship of the expression of myeloid leukemia gene-1(MCL-1)and NIK-IKK binding protein(NIBP)with tumor progression in colon cancer.【Methods】Immunohistochemical staining was used to detect the expression of MCL-1 protein and NIBP protein in 82 cases of postoperative colon cancer tissues and corresponding adjacent tissues.The pathological parameters such as different TNM stage,tumor differentiation degree and Iesion size were analyzed to reveal their relationship with positive expression rate of MCL-1 protein and NIBP protein.【Results】The positive rates of MCL-1 protein and NIBP protein in colon cancer tissues were 68.29%and 60.98%,respectively,which were significantly higher than those in adjacent tissues(26.83%and 20.73%,respectively).The differences were statistically significant(P<0.05).The differential expression of MCL-1 protein and NIBP protein in colon cancer tissues with different tumor invasion depths,TNM stages,pathological differentiation,and ljmiph node metastasis were statistically significant(P<0.05).【Conclusion】The expression of MCL-1 protein and NIBP protein in colon cancer tis-sues is significantly higher than that in adjacent tissues,which may be related to the progression of colon cancer.