赖氨酸特异性脱甲基酶2B与胃癌患者复发的相关性分析

KDM2B Expression Association with Gastric Cancer Recurrence

【目的】探讨赖氨酸特异性脱甲基酶2B(KDM2B)在胃癌组织中表达与术后复发的关系。【方法】在本院接收手术治疗的胃癌患者300例,检测KDM2B在胃癌组织中的表达,并随访复发情况。采用Kaplan-Meier并Log-rank检验进行单因素分析,将单因素有意义的因素引入Cox回归模型分析胃癌复发的相关性因素。【结果】根据TNM分期,300例患者中,Ⅰ期75例,Ⅱ期63例,Ⅰ期162例。278例患者完成随访,失访22例,随访率92.7%。平均随访时间(39.8±10.5)个月。123例患者(41%)符合KDM2B阳性标准。142例患者发生复发转移。单因素分析显示,较大肿瘤、较高T分期、N分期、TNM分期、KDM2B阳性表达可增加经手术治疗胃癌患者复发风险。Cox回归分析显示,与KDM2B表达阴性者相比,KDM2B表达阳性者术后复发风险增加98%[HR:1.98;95多CI:1.23~3.32]。【结论】KDM2B表达阳性是胃癌患者术后复发的独立危险因素,KDM2B表达阳性患者预后更差。

【Objective】To investigate the relationship of Lysine(K)-specific demethylase 2B(KDM2B)expression with gastric cancer recurrence.【Methods】Three hundred gastric cancer patients who received surgical treatment in our hospital were included in this study.The expression of KDM2B in gastric cancer tissues was detected and follow-up was conducted to determine the recurrence.Kaplan-Meier and log-rank test were used for univariate analysis,and significant factors in univariate analysis were introduced into Cox regression model.【Results】According to TNM staging,among the 300 patients selected,75 cases were categorized into stageⅠ,63 cases were in stageⅡ,and 123 cases were in stageⅢ.Follow-up was completed in 278 patients,While 22 cases were lost to follow-up.The follow-up rate was 92.7%.KDM2B positive expression was shown in 123 patients(41%).Recurrence and metastasis occurred in 142 patients.Univariate a-nalysis showed that larger tumors,higher T stage,higher N stage,later TNM stage and positive KDM2B expression in-creased the risk of recurrence in patients with gastric cancer after surgery.Cox regression analysis showed that,compared to patients with negative KDM2B expression,patients with positive KDM2B expression increased risk of gastric cancer re-currence by 98%[HR:1.98;95CI:1.23-3.32].【Conclusion】Positive KDM2B expression increases the risk of post-operative recurrence in patients with gastric cancer and patients with positive KDM2B expression have a worse prognosis.