卵巢癌患者血浆D-二聚体水平的变化及其与临床病理特征的关系

Plasma levels of D-dimer in patients with ovarian cancer and its relation to clinicopathologic characteristics of disease

目的探讨卵巢癌患者血浆D-二聚体水平变化的意义及其与临床病理因素的关系。方法回顾性选择2017年1月至2018年8月浙江省肿瘤医院首次诊治的268例卵巢肿物患者,应用免疫比浊法检测176例卵巢癌患者和92例卵巢良性肿瘤患者的血浆D-二聚体水平,采用单因素和多因素logistic回归分析血浆D-二聚体水平与卵巢癌临床病理因素的关系。结果卵巢癌患者血浆D-二聚体水平显著高于卵巢良性肿瘤患者(P<0.001);单因素分析和多因素logistic回归分析显示,血浆D-二聚体水平与卵巢癌患者的国际妇产科联盟(FIGO)分期密切相关(P<0.001);治疗后卵巢癌患者血浆D-二聚体水平明显降低(P<0.001)。结论卵巢癌患者治疗前存在凝血系统紊乱,血浆D-二聚体水平反映了卵巢癌的恶性程度,与卵巢癌的分期、进展等密切相关,因此D-二聚体水平在卵巢癌血清学诊断和临床应用研究中均有重要价值。

Objective To investigate the plasma D-dimer levels in patients with ovarian cancer,and the relationship between plasma D-dimer and clinical pathologic characteristics of disease.Methods A total of 268 patients with ovarian tumor who were diagnosed and treated by Zhejiang Cancer Hospital from January 2017 to August 2018 were retrospectively analyzed.Plasma D-dimer levels were measued by immunoturbidimetric assay in 176 ovarian cancer patients and 92 benign ovarian tumor patients.Univariate and multivariate logistic regression were used to analyze the relationship between plasma D-dimer and clinicopathological factors of ovarian cancer.Results The plasma D-dimer level in patients with ovarian cancer was significantly higher than that in patients with benign ovarian tumor(P<0.001);univariate analysis and multivariate logistic regression analysis showed that plasma D-dimer was closely related to International Federation of Gynecology and Obstetrics(FIGO)stage of ovarian cancer patients(P<0.001);the plasma D-dimer level of ovarian cancer patients after treatment was significantly decreased(P<0.001).Conclusions Patients with ovarian cancer has coagulation disorders before treatment.The level of plasma D-dimer reflects the malignant degree of ovarian cancer and is closely related to the stage and progress of ovarian cancer.The level of D-dimer has important value in serological diagnosis and clinical application of ovarian cancer.