组蛋白赖氨酸甲基转移酶NSD3在肿瘤发生中的作用

The role of histone lysine methyltransferase NSD3 in tumorigenesis

NSD3是具有致癌作用的组蛋白赖氨酸甲基转移酶(HKMTases)NSD(核受体结合SET结构域蛋白)家族的一员。近期许多研究表明NSD3在乳腺癌、急性髓性白血病、坚果中线癌、肺癌等多种恶性肿瘤中有促进肿瘤发生的作用,可与NUP98、NUT融合或与BRD4、CHD8、MYC等相互作用,形成致癌复合物;也可以通过调控H3K36me2水平或EGFR(K721)甲基化,加速细胞周期进程,促进肿瘤发生。NSD3不仅参与肿瘤的发生,还与肿瘤的不良预后及侵袭能力有关。本文对NSD3最新的研究进展进行归纳总结,探讨NSD3在肿瘤发生中的作用及潜在的应用前景。

NSD3 is a member of the nuclear receptor-binding SET domain(NSD)family of histone lysine methyltransferases(HKMTases),which play important roles in tumorigenesis.Many recent studies have shown that NSD3 can promote the occurrence of various malignant tumors such as breast cancer,acute myeloid leukemia,NUT midline cancer,and lung cancer.It can fuse with NUP98 and NUT,or interact with BRD4,CHD8,and MYC to form carcinogenic complexes.It can also accelerate cell cycle progression and promote tumorigenesis by regulating the levels of H3K36me2 or EGFR(K721)methylation.NSD3 is not only involved in the occurrence of tumors but also related to the poor prognosis and enhanced invasive ability of tumors.In this paper,the current progress of research regarding NSD3 is summarized and the role of NSD3 in tumorigenesis and its potential application prospects are explored.