不可分型流感嗜血杆菌外膜蛋白的研究进展

Research progress in outer membrane proteins ofnontypeable Haemophilus influenzae

不可分型流感嗜血杆菌(nontypeable Haemophilus influenzae,NTHi)是一种定植在人类鼻咽部常见的条件致病菌,常引起继发性感染,如支气管炎、鼻窦炎、儿童中耳炎和成人慢性阻塞性肺疾病急性加重等。研究发现该菌细胞壁外膜上表达多种具有免疫原性和抗原性的蛋白,其对该菌在宿主体内的定植、入侵和生存必不可少,有些蛋白还与该菌的耐药性和宿主免疫的清除机制有关。因此,研究外膜蛋白有利于开发有效的疫苗和抗感染药物来预防及治疗NTHi引起的感染,下面从蛋白的结构、功能及应用等方面对几种外膜蛋白作一综述。

Nontypeable Haemophilus influenzae(NTHi)is a conditioned pathogen colonizing the human nasopharynx.It often causes secondary infections,such as bronchitis,sinusitis,otitis media in children,and acute exacerbations of chronic obstructive pulmonary disease in adults.It has been found that a variety of immunogenic and antigenic proteins are expressed on the outer membrane of the cell wall of NTHi,which are essential for its colonization,invasion,and survival in the host.In addition,some proteins are also associated with the drug resistance and host immune clearance mechanism of the bacterium.Therefore,the study of outer membrane proteins is beneficial to the development of effective vaccines and anti-infective drugs to prevent and treat infections caused by NTHi.In this paper,several outer membrane proteins are reviewed in terms of their structure,function and application.