热带假丝酵母菌生物膜形成机制及其抗性研究

Formation mechanism and resistance study of Candida tropicalis biofilm

热带假丝酵母菌已成为第3种最常见的真菌病原体,其形成生物膜的能力被认为是最重要的毒力因子之一。热带假丝酵母菌的生物膜是住院患者发病率和死亡率较高的独立危险因素,且与感染患者的不良预后有关。但是,对热带假丝酵母菌生物膜的研究少且分散。为此,本文将从环境因素、基因调控、抗性和抗性机制等多方面对热带假丝酵母菌生物膜进行系统全面的综述。

Candida tropicalis has become the third most common fungal pathogen,and its ability to form biofilms is considered as one of the most important virulence factors.The biofilm of Candida tropicalis is an independent risk factor for high morbidity and mortality in inpatients,and is associated with poor prognosis in infected patients.However,studies on Candida tropicalis biofilms are rare and scattered.For this reason,this paper will provide a systematic and comprehensive review of Candida tropicalis in terms of environmental factors,gene regulation,resistance,and resistance mechanisms.