抗抑郁药物起效时间的研究进展

Research progress of onset time of antidepressants

抑郁症作为一种慢性精神疾病,具有高患病率、高复发率、高自杀、致残率的特点。药物治疗作为当前的主要治疗手段,其起效快慢一直备受临床医护工作者的关注,抗抑郁药的合理使用可以增强患者服药依从性并降低其自杀风险。现对各类抗抑郁药的起效时间、影响抗抑郁药起效时间的相关要素、个别抗抑郁药增效剂加速其起效的机制三个方面进行综述。

As a chronic mental disease,depression has the characteristics of high morbidity,high recurrence rate,and high suicide and disability rate.Drug therapy,as the main treatment method at present,has been attracting the attention of clinical medical workers for its onset rate(its rapid onset and slow response).Rational use of antidepressants can enhance patients'medication compliance and reduce their suicide risk.This paper summarizes the research progress on the overview of the onset time of various antidepressants,the relevant factors affecting the onset time of antidepressants,and the mechanism by which individual antidepressant synergist accelerates the onset time of antidepressants,so as to provide reference for medical staff and literature basis for accurate decision-making of drug use.