宣肺利水固本方治疗特发性羊水过多72例临床研究

Clinical Study on 72 Cases of Idiopathic Polyhydramnios Treated by Xuanfei Lishui Guben Recipe

目的:观察宣肺利水固本方治疗特发性羊水过多的临床效果。方法:选取2018年1月~2018年12月在北京市通州区妇幼保健院产科诊治的72例特发性羊水过多孕妇为研究对象,采用随机分组方法分为对照组和研究组,每组均36例。对照组给予常规西医治疗,研究组在常规西医治疗基础上给予宣肺利水固本方中药治疗,比较两组临床疗效、母婴并发症和安全性等情况。结果:两组均无脱落或剔除病例,治疗后"腹胀"、"胸闷"、"口渴"、"下肢肿"和"气急"5项主要症状积分均较本组治疗前明显下降(P<0.05),研究组治疗后上述症状积分均显著低于对照组,差异有统计学意义(P<0.05);研究组治疗后羊水指数(AFI)显著低于对照组,临床总有效率83.33%明显高于对照组61.11%,差异均有统计学意义(P<0.05);研究组早产、胎膜早破、胎儿窘迫、产后出血和新生儿窒息发生例数均少于对照组,且早产、胎膜早破发生率显著低于对照组,差异有统计学意义(P<0.05);两组治疗均未出现明显不良反应,安全性评价均为1~2级。结论:宣肺利水固本方中药治疗特异性羊水过多临床疗效显著,能明显减轻患者症状程度和减少母婴并发症发生,且安全性好,适合临床推广运用。

Objective:To explore the clinical effect of using Xuanfei Lishui Guben Recipe in the treatment of idiopathic amniotic fluid excess from the perspective of traditional Chinese medicine.Methods:from January 2018 to December 2018,72 pregnant women with idiopathic polyhydramnios who were diagnosed and treated in the TCM obstetrics department of Tongzhou District Maternal and Child Health Care Hospital of Beijing were selected as the study objects.They were randomly divided into control group and study group with 36 cases in each group.The controlled group was treated with conventional western medicine,while the study group was treated with traditional Chinese medicine based on the conventional western medicine.The clinical effect,complications and safety of the two groups were compared.Results:There were no cases dropped or excluded in the two groups.After treatment,the scores of the five main symptoms of"abdominal distension","chest distress","thirst","swelling of lower limbs"and"shortness of breath"were significantly lower than those before treatment in the study group(P<0.05).The scores of the above symptoms in the study group were significantly lower than those in the controlled group(P<0.05).After treatment,the AFI of the study group was significantly lower than that of the controlled group,and the total clinical effective rate was 83.33%which was significantly higher than that of the controlled group,which was 61.11%,the difference was statistically significant(P<0.05).The incidence of premature delivery,premature rupture of membranes,fetal distress,postpartum hemorrhage and neonatal asphyxia in the study group were lower than that in the controlled group,and the incidence of premature delivery and premature rupture of membranes was significantly lower than that in the controlled group(P<0.05).There were no significant adverse reactions in the two groups,and the safety evaluation was 1~2 grade.Conclusion:Using Xuanfei Lishui Guben Recipe of traditional Chinese medicine in the treatment of specific amniotic fluid excess has significant clinical efficacy,can significantly reduce the degree of symptoms and reduce the incidence of maternal and infant complications,and safety,suitable for clinical application.