钙离子调控蛋白在肿瘤血管形成及肿瘤发展中的研究进展

Function of calcium regulating protein in tumor angiogenesis and tumor progression

[目的]探讨钙离子调控蛋白在肿瘤血管生成及肿瘤发展中的作用。[内容]Ca^2+作为第二信使参与生命活动中多种途径的调控,钙离子调控蛋白作为Ca^2+的生物信息传递载体在此过程中起着重要作用。肿瘤组织中血管内皮细胞及平滑肌细胞的激活是肿瘤新生的第一步,新生血管的形成能促进实体瘤生长、侵袭和转移。该文综述了参与钙离子浓度调控的钙调控蛋白S100蛋白、膜联蛋白(Annexin)、钙网蛋白(CRT)、钙调蛋白CaM及其他非直接钙离子结合的钙调控蛋白,这些蛋白在肿瘤细胞中的表达水平,及如何通过调控血管内皮细胞及平滑肌细胞的功能进而影响肿瘤血管生成与肿瘤转移,该综述聚焦重点是肺癌的研究,也对其他常见癌症有涉及。[结论]钙离子调控蛋白是一种重要的调节血管形成和肿瘤发展的一类蛋白,是肿瘤发展的标志物及肿瘤治疗的潜在靶点。

[Objective]To summarize the function of calcium regulating protein in tumor angiogenesis and tumor regression.[Review]Calcium ion as the second messenger participates in the regulation of many pathways in biological activities.As the biological information carrier of Ca^2+,Calcium regulating protein plays a key role in this process.The endothelial cell and smooth muscle cell activation and proliferation is the first step in formation and development of the capillary network that supplies the tumor.Angiogenesis is a key event in the growth,invasion and metastasis of solid tumors.Members of the calcium regulating protein family:S100 protein,Annexin(Annexin),Cacy BP,calreticulin(CRT),calmodulin Ca M,and other indirect calcium binding protein can regulate the calcium concentration in cells,thus regulate signaling pathway and endothelial smooth muscle cell function,participate in tumor angiogenesis and metastasis.This review focuses on the role of calcium regulating protein family members in tumor angiogenesis and metastasis,focusing on lung cancer,as well as other common cancers.[Conclusion]Calcium regulating proteins are key proteins in regulating tumor angiogenesis and tumor regression.Calcium regulating proteins are the markers of tumor progression and potential therapeutic targets for cancer therapy.