诱导多能干细胞在骨外科组织工程中的应用与作用

Application and effect of induced pluripotent stem cells in bone surgery tissue engineering

背景:诱导多能干细胞具备分化全能性、来源广泛、易获得并且没有伦理约束等诸多优点,使其迅速成为组织工程领域有前途和希望的种子细胞。目的:对诱导多能干细胞在骨外科组织工程中的应用进展作一综述。方法:由第一作者检索PubMed数据库,检索主题词为“iPSCs,osteanagenesis,tendon,spinal cord,spinal cord,tissue engineering,regenarative medicine”,查找在2000至2020年发表的相关研究。筛选关联性强的,排除与文章写作内容不大的文献,共选取50篇参考文献进行综述。结果与结论:与间充质干细胞、胚胎干细胞等相比,诱导多能干细胞具有来源广、易获取、不受伦理约束以及可调控基因不稳定性、减少免疫排斥等优点,在骨外科组织工程研究运用中展现出满意的治疗结果。

BACKGROUND:Induced pluripotent stem cells have many advantages such as differentiation totipotency,wide source,easy access and no ethical constraints,so they rapidly become promising seed cells in the field of tissue engineering.OBJECTIVE:To review the progress of induced pluripotent stem cells in bone surgery tissue engineering.METHODS:The electronic database PubMed was searched by the first author.The key words were“iPSCs,osteanagenesis,tendon,spinal cord,spinal cord,tissue engineering,regenarative medicine”.The literature published from 2000 to 2020 was searched.A total of 50 articles were selected as references for review,screening the documents with strong relevance and excluding those with little content.RESULTS AND CONCLUSION:Compared with mesenchymal stem cells and embryonic stem cells,induced pluripotent stem cells have many advantages,such as wide source,easy access,no ethical constraints and controllable gene instability,reducing immune rejection.Induced pluripotent stem cells technology in bone surgery tissue engineering research showed satisfactory results.