膀胱癌干细胞标志物及相关信号通路:抗体靶向治疗思路

Bladder cancer stem cell markers and related signaling pathways:antibody targeted therapy

背景:膀胱癌是泌尿系统中最常见的恶性肿瘤之一,严重威胁患者的生命健康。膀胱癌干细胞的不断深入研究为膀胱癌治愈提供了新的治疗方向,近年来对膀胱癌干细胞重要标志物和信号通路的研究为膀胱癌靶向治疗提供了有力依据。目的:综述近年来国内外对膀胱癌干细胞主要标志物和信号通路的研究进展。方法:计算机检索中国期刊全文数据库(CNKI)和PubMed数据库2004至2020年的相关文献,中文检索词为“膀胱癌,肿瘤干细胞”;英文检索词为“bladder cancer,cancer stem cells(CSCs)”,选择与膀胱癌干细胞标志物和信号通路方面相关的文章,并对重要标志物和信号通路在膀胱癌起始、复发、转移和耐药等行为中的作用进行总结、整理和论述。结果与结论:膀胱癌干细胞标志物和信号通路在膀胱癌的发生、发展、浸润、转移及耐药过程中扮演重要角色,对它们的深入研究能为进一步开展针对肿瘤干细胞的抗体靶向治疗提供新思路。

BACKGROUND:Bladder cancer is one of the most common malignancies of the urinary system and is a serious threat to patient.The continuous in-depth study of cancer stem cells provides a new therapeutic direction for the cure of bladder cancer,in which important markers and signaling pathways of bladder cancer stem cells provide a strong basis for targeted therapy of bladder cancer.OBJECTIVE:To review the research progress of major markers and signaling pathways of bladder cancer stem cells.METHODS:A computer-based search for articles published from 2004 to 2020 was performed in CNKI and PubMed databases.The key words were“bladder cancer,cancer stem cells(CSCs)”in Chinese and English.We selected articles related to bladder cancer stem cell markers and signaling pathways,and summarized,sorted and discussed the role of important markers and signaling pathways in the initiation,recurrence,metastasis and drug resistance of bladder cancer.RESULTS AND CONCLUSION:The markers and signaling pathways of bladder cancer stem cells play an important role in the development,progression,invasion,metastasis,and drug resistance of bladder cancer.The further study of them can provide new ideas for the further development of antibody targeted therapy against cancer stem cells.