长链非编码RNA在脓毒症相关器官损伤中致病机制的研究进展

Research Progress on the Pathogenic Mechanism of Long Non-coding RNA in Sepsis-related Organ Damage

脓毒症是机体对感染反应失控引起的致命性器官功能障碍。长链非编码RNA(lncRNA)是一种长度超过200个核苷酸的非编码转录物,主要分布在细胞质和细胞核,参与炎症反应、器官功能障碍中的各种信号通路,发挥相应的作用。本文总结了关于lncRNA在脓毒症引起的肾损伤、心肌损伤、肺损伤和肝损伤等机制中的研究,分析lncRNA在脓毒症致病机理中所起到的作用,探讨lncRNA作为脓毒症相关器官损伤潜在生物标志物的可能性。

Sepsis is a fatal organ dysfunction caused by the body's uncontrolled response to infection.Long-chain non-coding RNA(lncRNA)is a non-coding transcript with a length of more than 200 nucleotides,mainly distributed in the cytoplasm and nucleus,and is involved in the role of various signaling pathways in inflammation and organ dysfunction.This article summarizes the research on lncRNA about the mechanism of kidney damage,myocardial damage,lung damage and liver damage caused by sepsis,analyzes the role of lncRNA in the pathogenic mechanism of sepsis,and explores the role of lncRNA sepsis and in the possibility of potential biomarkers of related organ damage.