免疫炎症反应在抑郁症中作用的研究进展

Research Progress on the Role of Immune Inflammatory Response in Depression

抑郁症是一种常见的情感性障碍,其发病机制复杂,发病率逐年升高。现有越来越多的证据表明,抑郁症与免疫炎症反应密切相关,抑郁症患者体内促炎症细胞因子及其受体的表达增加,免疫调节细胞具有减轻炎症和支持神经元完整性的作用,炎症反应参与神经递质系统的代谢和分子通路,从而影响脑部结构和功能。本文就免疫炎症反应与抑郁症之间的关联及可能的作用机制,以及炎性因子在抑郁症治疗方面的影响进行综述,为抑郁症发病机制和个性化的治疗提供新的思路。

Depression is a common emotional disorder and its pathogenesis is complex,and the incidence rate is increasing year by year.Increasing evidence shows that depression is closely related to immune inflammatory response.The expression of pro-inflammatory cytokines and their receptors in patients with depression is increased.Immune regulatory cells can reduce inflammation and support the integrity of neurons.Inflammatory response is involved in metabolism and molecular pathway of neurotransmitter system,thus affecting the structure and function of the brain.This paper reviews the relationship between immune inflammatory response and depression and the possible mechanisms,as well as the impact of inflammatory factors in the treatment of depression,and provide new ideas for pathogenesis and personalized treatment of depression.