组蛋白乙酰化在肝纤维化中的研究进展

Research progress of histone acetylation in liver fibrosis

肝纤维化是肝损伤的重要病理修复过程,主要表现为肝星状细胞的增殖、活化以及所致的细胞外基质过度沉积。组蛋白乙酰化是最常见的表观遗传修饰之一,在染色质重塑和基因表达调控中发挥关键作用。研究表明,在肝纤维化进程中观察到组蛋白乙酰化的位点及水平发生改变。组蛋白乙酰化主要由组蛋白乙酰转移酶(histone acetyltransferase,HAT)和组蛋白去乙酰化酶(histone deacetylase,HDAC)两类酶调控,二者失衡会导致病理变化。当前许多研究已经对HAT和HDAC在肝纤维化起始和进展中的作用进行了深入探讨。该文就近年来组蛋白乙酰化在肝纤维化中的研究作一综述,旨在为肝纤维化的病理机制研究与相关治疗药物的研发提供新的视角和靶标。

Liver fibrosis is an important pathological repair process of liver injury,which is mainly manifested by the proliferation,activation of hepatic stellate cells,and excessive deposition of extracellular matrix.Histone acetylation is one of themost common epigenetic modifications and plays a key role in chromatin remodeling and gene expression regulation.Studies have shown that changes in the sites and levels of histone acetylation are observed during liver fibrosis.Histone acetylation is regulated by histone acetyltransferase(HAT)and histone deacetylase(HDAC).Imbalance of HAT and HDAC can cause pathojulogical changes.Many studies have investigated the role of HAT and HDAC in the initiation and progression of liver fibrosis.This article reviews the recent research on histone acetylation in liver fibrosis in order to provide new perspectives and targets for the pathological mechanism of liver fibrosis and the development of related therapeutic drugs.