舒肝宁注射液与5%葡萄糖注射液配伍稳定性研究

Study of Compatible Stability on ShuGanNing Injection and 5%Glucose Injection

目的探讨舒肝宁注射液与5%葡萄糖注射液配伍的稳定性。方法舒肝宁注射液依照临床使用的质量浓度与5%葡萄糖注射液配伍。依照《中国药典》的方法分别检测成品溶液放置0、2、4、6 h后的外观、pH值、不溶性微粒数量的变化,同时采用HPLC检定成品溶液中绿原酸、栀子苷、黄芩苷、黄芩素、野黄芩苷的含量。结果成品溶液的外观、pH值、各有效成分含量于6 h内无明显的变化;不溶性微粒数量于4 h内基本符合标准,但6 h内其数量是逐渐增加。结论舒肝宁注射液与5%葡萄糖注射液配伍在4 h内稳定。

OBJECTIVE To study the stability of ShuGanNing injection combined with 5%Glucose Injection.METHODS ShuGanNing injection were mixed with 5%Glucose injection according to mass concentration in the clinic respectively.According to Chinese Pharmacopeia,the fluid compatibility testing of the appearance,value of pH,insoluble particles were performed at 0,2,4,6h after the preparation.Chlorogenic acid,geniposide,scutellarin,baicalin,baicalein were deter mined by HPLC.RESULTS The appearance,pH,and active ingredient content of finished produce show no maked change within 6 h.The amount of insoluble granule in finished fluid is standard within 4 h.And the amount of insoluble granule in finished fluid continued to increase within 6 h.CONCLUSION The compatibility of Shuganning Injection with 5%Glucose Injection is stable within 4 h.