大剂量氨溴索在重症肺炎治疗中的效果和不良反应观察

Effect of High-dose Ambroxol in the Treatment of Severe Pneumonia and Observation of Adverse Reactions

目的探究大剂量氨溴索在重症肺炎治疗中的效果以及不良反应情况。方法选取2018年1月至2019年8月重庆市巫山县人民医院收治的100例重症肺炎患者,采用随机数字表法分组,对照组给予常规剂量氨溴索治疗,试验组给予大剂量氨溴索治疗。比较两组重症肺炎患者治疗效果、不良反应、症状消失时间、治疗前后肺功能指标水平的差异性。结果试验组患者的总有效率为96.00%,高于对照组的64.00%(P<0.05);试验组肺部湿啰音消失、气促消失、咳嗽消失、退热时间均低于对照组(P<0.05);试验组治疗后的1s用力呼吸量(FEV1)、用力肺活量(FVC)、最大呼气峰流速(PEF)、第1s用力呼气容积占用力肺活量比值(FEV1/FVC)水平高于对照组(P<0.05);两组患者不良反应发生率相比较,差异无统计学意义(P>0.05)。结论重症肺炎患者接受大剂量氨溴索治疗,可获得较好的效果,且不会明显增加患者不良反应的发生率。

Objective To explore the effect and adverse reactions of high dose ambroxol in the treatment of severe pneumonia.Methods A total of 100 patients with severe pneumonia admitted to Wushan County People's Hospital from January 2018 to August 2019 were selected and divided into groups by random number table method.The control group was given routine dose ambroxol treatment,while the experimental group was given high-dose ambroxol treatment.The differences of treatment effect,adverse reaction,symptom disappearance time,lung function index level before and after treatment were compared between the two groups.Results The total effective rate in the experimental group was 96.00%,higher than that in the control group 64.00%(P<0.05).The disappearance of moist rhonchus,shortness of breath,cough and antifebrile time in the experimental group were all lower than those in the control group(P<0.05).The ratio of forced expiratory volume(FEV1),forced vital capacity(FVC),maximum expiratory peak flow rate(PEF)and forced expiratory volume to forced vital capacity(FEV1/FVC)in the experimental group was higher than that in the control group(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion High-dose ambroxol treatment in patients with severe pneumonia can achieve better results and will not significantly increase the incidence of adverse reactions.