阿尔茨海默病患者血清胆红素水平与血脂的相关性研究

Correlation Between Serum bilirubin Level and Blood Lipid in Patients with Alzheimer's Disease

目的对阿尔茨海默病患者的血清胆红素和血脂水平进行检测,分析三者之间的相关性。方法选取重庆市合川区人民医院门诊及病房2018年10月至2019年12月符合纳入标准的30例阿尔茨海默病患者入观察组,选择同一时期在体检中心进行体检的认知功能正常的老年人30例作为健康对照组,进行对照研究,通过比较两组人员的血清胆红素水平(血清总胆红素、直接胆红素、间接胆红素)和血脂水平(总胆固醇、三酰甘油、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇),观察分析阿尔茨海默症与血清胆红素、血脂的关系,并探讨阿尔茨海默症患者血清胆红素与血脂的可能相关性。结果观察组患者的血清总胆红素、直接胆红素、间接胆红素水平显著低于健康对照组(P<0.05);观察组患者的总胆固醇、三酰甘油、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇分别为(3.0±1.1)mmol/L,(1.0±1.1)mmol/L,(0.9±0.5)mmol/L,(1.6±0.9)mmol/L,健康对照组的总胆固醇、三酰甘油、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇分别为(4.0±1.0)mmol/L,(2.1±1.5)mmol/L,(1.1±0.1)mmol/L,(1.7±0.5)mmol/L,两组患者总胆固醇、三酰甘油比较,差异具有统计学意义(P<0.05),高密度脂蛋白胆固醇、低密度脂蛋白胆固醇差异无统计学意义(P>0.05)。阿尔茨海默症患者的血清总胆红素水平与总胆固醇、三酰甘油均呈负相关,差异有统计学意义(P<0.05)。结论阿尔茨海默症与血清胆红素、血脂水平具有密切关系,同时,阿尔茨海默病患者血清胆红素水平与血脂有相关性。

Objective To detect the serum bilirubin and serum lipid levels in patients with Alzheimer's disease and analyze the correlation between them.Methods Selection of Hechuan District People's Hospital outpatient and ward from October 2018 to December 2019,included in the standard of 30 cases of Alzheimer's patients into the observation group,choose the same period in a medical center for a medical cognitive functioning as a healthy control group of 30 cases of the elderly,comparison research,by comparing the two groups of serum bilirubin level,serum total bilirubin,direct bilirubin,indirect bilirubin and lipid levels(three acyl glycerin,total cholesterol,high-density lipoprotein cholesterol,low density lipoprotein cholesterol),observing and analyzing the relationship of AD and serum bilirubin,blood lipid,To explore the possible correlation between serum bilirubin and blood lipid in AD patients.Results The serum levels of total bilirubin,direct bilirubin and indirect bilirubin in the observation group were significantly lower than those in the healthy control group(P<0.05).The total cholesterol,triacylglycerol,high-density lipoprotein cholesterol,and low-density lipoprotein cholesterol in the observation group were(3.0±1.1)mmol/L,(1.0±1.1)mmol/L,(0.9±0.5)mmol/L,and(1.6±0.9)mmol/L,respectively,and the total cholesterol,triacylglycerol,high-density lipoprotein cholesterol,and lowdensity lipoprotein cholesterol in the healthy control group were:(4.0±1.0)mmol/L,(2.1±1.5)mmol/L,(1.1±0.1)mmol/L,(1.7±0.5)mmol/L.The differences in total cholesterol and triacylglycerol between the two groups were statistically significant(P<0.05),while the differences in HDL cholesterol and LDL cholesterol were not statistically significant(P>0.05).The serum total bilirubin level in AD patients was negatively correlated with total cholesterol and triglyceride,and the difference was statistically significant(P<0.05).Conclusion There is a close relationship between serum bilirubin and serum lipid level in Alzheimer's disease,and there is a correlation between serum bilirubin level and serum lipid level in Alzheimer's disease patients.