低分子肝素联合气压治疗在腹腔镜妇科恶性肿瘤术后血栓性疾病的防治临床疗效观察

Observation of the clinical efficacy of low molecular weight heparin combined with air pressure treatment in preventing and treating thrombotic diseases after laparoscopic surgery for gynecological malignant tumors

目的探讨低分子肝素联合气压治疗在腹腔镜妇科恶性肿瘤术后血栓性疾病的防治临床效果。方法选择我院2016年1月~2019年5月收治的126例腹腔镜妇科恶性肿瘤术患者作为研究对象,按照随机数字表法分组,试验组(42例)采用低分子肝素+气压治疗方法;参照组1(42例)采用低分子肝素治疗方法;参照组2(42例)未采用上述治疗方法。比较分析组间血清学指标水平、下肢静脉血栓发生率、下肢疼痛、下肢水肿以及下肢疼痛伴下肢水肿总比例。结果试验组腹腔镜妇科恶性肿瘤术患者D-二聚体水平以及纤维蛋白原水平均明显低于参照组1以及参照组2,血小板计数高于参照组1以及参照组2,差异有统计学意义(P<0.05);试验组腹腔镜妇科恶性肿瘤术患者下肢静脉血栓发生率低于参照组1以及参照组2,差异有统计学意义(P<0.05);试验组患者下肢疼痛、下肢水肿以及下肢疼痛伴下肢水肿总比例低于参照组1以及参照组2,差异有统计学意义(P<0.05)。结论腹腔镜妇科恶性肿瘤术患者于临床接受低分子肝素+气压治疗后,利于血清学指标的改善,术后血栓性疾病的发生率显著降低,可促进妇科恶性肿瘤患者的预后改善。

Objective To probe into the clinical efficacy of low molecular weight heparin(LMWH)combined with air pressure treatment in preventing and treating thrombotic diseases after laparoscopic surgery(LS)for gynecological malignant tumors.Methods From January 2016 to May 2019,a total of 126 patients having undergone LS for gynecological malignant tumors admitted to and treated in our hospital were selected as the subjects of research.After they were divided into different groups through random number table method.For the experimental group(n=42),LMWH combined with air pressure treatment was adopted;for the reference group 1(n=42),the LMWH therapy was adopted;for the reference group 2(n=42),the above-mentioned therapies were not adopted.Among these groups,comparisons were made in the levels of serological indexes,the incidence of venous thrombosis of the lower limbs,and the total proportion of pain of the lower limbs,edema of the lower limbs and pain companied by edema of the lower limbs.Results The D-dimer level and the fibrinogen level of the patients having undergone LS for gynecological malignant tumors in the experimental group were both significantly lower than those in the reference group 1 and the reference group 2,and the blood platelet count was significantly higher than that in the reference group 1 and the reference group 2,with statistically significant differences(P<0.05).The incidence of venous thrombosis of the lower limbs among the patients having undergone LS for gynecological malignant tumors in the experimental group was lower than that in the reference group 1 and the reference group 2,and the differences were statistically s i g n i f i c a n t(P<0.05).The total proportion of pain of the lower limbs,edema of the lower limbs and pain companied by edema of the lower limbs of the patients in the experimental group was lower than that in the reference group 1 and the reference group 2,and the differences were statistically significant(P<0.05).Conclusion On receiving LMWH combined with air pressure treatment in clinical practice,the patients having undergone LS for gynecological malignant tumors can have their serological indexes ameliorated and the incidence of postoperative thrombotic diseases significantly reduced,ultimately promoting the improvement of the prognosis of the patients with gynecological malignant tumors.