circRNA及其调控动物骨骼肌发育研究进展

circRNA on animal skeletal muscle development regulation

环状RNA(circular RNA,circRNA)是一类反向剪接形成的闭合环状RNA分子,广泛存在于生物体内,近年来成为非编码RNA中的研究热点。骨骼肌在生物体中起到协调运动的作用,是维持体内正常代谢和内分泌的器官之一。随着测序技术和生物信息学分析技术的发展,circRNA在动物骨骼肌发育中的功能和调控机制逐渐被揭示。本文就当前circRNA的分子调控机制类型、circRNA经典研究思路及功能研究方法以及circRNA参与骨骼肌正常发育与骨骼肌疾病发生调控的研究进展进行了综述,以期为进一步深入研究circRNA参与骨骼肌生长发育调控的遗传机制以及circRNA相关研究方法提供参考。

Circular RNA(circRNA)is a type of closed circular RNA molecules formed by reverse splicing,which exists widely in organisms and has become a research hotspot in non-coding RNAs in recent years.Skeletal muscle plays the role of coordinating movement and maintaining normal metabolism and endocrine in organisms.With the development of sequencing and bioinformatics analysis technology,the functions and regulation mechanisms of circRNAs in skeletal muscle development have been gradually revealed.In this review,we summarize the types of molecular regulatory mechanisms,the classical research ideas and the functional research methods of circRNAs,and the research progress of circRNAs involved in normal development of skeletal muscle and regulation of skeletal muscle disease,in order to provide a reference to further study of the genetic mechanisms of circRNAs in the regulation of skeletal muscle development.