血清白蛋白与对比剂诱导的急性肾损伤的研究进展

Research Progress on Renal Damage of Serum Albumin and Contrast-Induced Acute Kidney Injury

对比剂诱导的急性肾损伤(CI-AKI)是各种碘对比剂的相关诊疗措施的主要并发症。随着皮冠状动脉介入治疗(PCI)在临床上的广泛应用,CI-AKI越来越引起人们的注意。受制于基础医学研究进展,现今对CI-AKI病理生理机制的正确认识依旧非常有限。近年来,血清白蛋白水平作为敏感性好、特异性高的肾小管损伤标志物已在实验研究和临床观察中得到了验证。现就血清白蛋白作为早期诊断CI-AKI的生物标志物的研究进展进行综述。

Contrast-induced acute kidney injury(CI-AKI)is a major complication of various iodine contrast-related diagnostic and therapeutic measures.With the wide application of percutaneous coronary intervention(PCI)in clinical practice,CI-AKI has attracted more and more attention.Due to the progress of basic medical research,the correct understanding of the pathophysiological mechanism of CI-AKI is still very limited.Therefore,it is of great significance to establish early prevention and recognition of CI-AKI and reduce complications of AKI in patients with PCI.