盐酸右美托咪定干预肠梗阻患者的效果、炎症因子水平及胃肠功能变化的临床观察

Intervention Role of Dexmedetomidine Hydrochloride on Curative Efficacy,Levels of Inflammatory Factors,and Gastrointestinal Function of Intestinal Obstruction Patients:Clinical Observation

为观察盐酸右美托咪定干预肠梗阻患者的效果、炎症因子水平及胃肠功能变化,将行手术治疗的80例肠梗阻患者随机分为对照组和观察组,每组40例。2组患者常规麻醉,切皮10min前观察组患者泵注盐酸右美托咪定,对照组患者泵注生理盐水,观察比较2组患者术后治疗效果、炎症因子水平及胃肠功能变化。结果显示,观察组患者治疗总有效率高于对照组(P<0.05),术后7d观察组患者IL-6及TNF-α水平低于对照组(P<0.05),术后7d观察组患者GSRS评分低于对照组(P<0.05)。结果表明,盐酸右美托咪定能有效缓解肠梗阻患者临床症状,提高其治疗效果,降低炎症因子水平,对改善机体胃肠功能具有促进作用。

This study was to observe the intervention role of dexmedetomidine hydrochloride(DH)on curative efficacy,levels of inflammatory factors(IF),and gastrointestinal function of patients with intestinal obstruction(IO),randomly divided 80 IO patients undergoing surgery into control group and observation group,40 cases per group;both groups were under routine anesthesia,10 min before incision of skin,pumping DH into patients’body of observation group,while in control group,replacing DH with saline;then,observed and compared both groups’efficacy curative,patients’IF levels and gastrointestinal function changes.As results,in total effective rate,in the levels of IL-6 and TNF-αat 7 days after surgery,and in GSRS score,observation group was respectively higher,lower,and lower than control group(all,P<0.05).Results show that DH can effectively relieve clinical symptoms of IO patients,enhance effect,and decrease patients’IF levels,so that promote gastrointestinal function improved.