3-(4-氟-苯基)-5-异丙基-2-苯基-吡咯-1-羧酸苯基酰胺的合成

SYNTHESIS OF 3-(4-FLUORO-PHENYL)-5-ISOPROPYL-2-PHENYL-PYRROLE-1-CARBOXYLICACID PHENYLAMIDE

在强碱催化下,甲基异丙酮和4-氟苯甲醛通过羟醛缩合反应得到α,β-不饱和酮2,然后与苯甲醛生成1,4-二酮化合物,将其与醋酸铵在醋酸催化下一锅法得到吡咯化合物,最后在叔丁基锂强碱作用下,与苯基异氰酸酯反应得到目标产物吡咯羧酸苯基酰胺类化合物。

α,β-unsaturated ketone is synthesized by aldol reaction of 4-fluorobenzaldehyde and methyl isopropyl ketone in presence of 15%KOH solution,then it reacts with benzaldehyde again for generating 1,4-diketones compound,which reacts with NH4OAc under AcOH catalysis by one-pot synthesis and pyrrole compound is obtained.And finally,under the catalytic action of a strong base of tert-butyllithium,pyrrole compound react with isocyanato-benzene for the target product of phenylamide compounds of pyrrolidine carboxylate.