从“卫强营弱”探讨结缔组织病相关间质性肺病之自身免疫机制

Discussion on the autoimmune mechanism of connective tissue disease-associated interstitial lung disease from‘strong defense and weak construction’

以“卫强营弱”为理论指导,结合现代临床与实验研究,对结缔组织病相关间质性肺病进程中自身免疫机制进行分析和归纳,认为卫强营弱是结缔组织病相关间质性肺病的病机之一。分而言之,卫气强盛可造成自身免疫应答过度活化,攻击自身正常结缔组织;营气羸弱可导致人体滋养濡润作用减弱,肺叶津枯,形成以肺痿为代表的肺部慢性虚损性疾患。当卫强营弱病机存在时,自身免疫机制激活,表现为结缔组织病相关间质性肺病。临床应用桂枝、白芍核心药对治疗该种疾病,切中卫强营弱之病机,具有一定可行性,具有推广价值。

Guided by the theory of‘strong defense and weak construction’and combined with modern clinical and experimental research,the autoimmune mechanism in the process of connective tissue disease-associated interstitial lung disease was analyzed and summarized in this paper.And it is believed that‘strong defense and weak construction’is one of the pathogenesis of connective tissue disease-associated interstitial lung disease.In other words,the strong defensive qi can cause the over activation of the autoimmune response,attacking the normal connective tissue of the body,the weak nutrition qi can cause the weakening of nourishing and moistening function of human body,and body fluid being deficient in lung lobe,forming pulmonary impotence as a representative of chronic pulmonary asthenia disease.The clinical application of herb pairs of cassia twig and white peony root treating this disease,hitting the pathogenesis of‘strong defense and weak construction’,is feasible and valuable for promotion.