代谢组学在银屑病中医证治研究中的应用与思考

Application and thinking on metabolomics in the study of TCM syndrome’s treatment of psoriasis

代谢组学因其整体性、动态性的方法学特点,被广泛运用于中医药相关科学问题的研究。本文概述当前代谢组学在银屑病中医证治研究中的应用现状,并浅析其中存在的问题。代谢组学在银屑病血热、血燥、血瘀证的证候本质研究方面取得一定进展,但实验分组设置尚欠严谨,且结果解读缺乏与中医证候特点的融合。代谢组学在银屑病相关中药复方“凉血解毒汤”“银屑1号方”“银屑灵”以及耳穴的疗效及作用机制研究中发挥重要作用,但临床样本不可控因素多,且结论分析大多是初步、片面的,可信度不高。总之,代谢组学在银屑病中医证治研究中具有应用价值及一定优势,但以上问题仍亟待解决。

Metabonomics has been widely used in the study of TCM related scientific issues due to its holistic and dynamic methodological characteristics.In this paper,the application of metabonomics in the study of TCM syndrome treatment of psoriasis was summarized,and the existing problems were analyzed.Metabonomics has made some progress in the study of the essence of the syndromes of blood-heat,blood dryness and blood stasis in psoriasis,but the experimental grouping is not yet rigorous,and the interpretation of the results lacks fusion with the characteristics of TCM syndromes.Metabolomics plays an important role in the study on the efficacy and mechanism of TCM compounds related to psoriasis,such as‘Laingxue Jiedu decoction’,‘Yinxie No.1 Prescription’,‘Yinxieling’and auricular-point.However,there are many uncontrollable factors in clinical samples,and most of the conclusions and analyses are preliminary and one-sided,with low credibility.In conclusion,metabonomics has application value and certain advantages in the study of TCM syndrome treatment of psoriasis,but the above problems still need to be solved urgently.