人体成分分析在评估慢性放射性肠炎营养状态中的应用

Application of the body composition analysis in evaluating the nutritional status of patients with chronic radiation-induced intestinal injury

目的:通过人体成分分析方法评估慢性放射性肠炎患者的营养状况,探讨人体成分分析的临床应用价值。方法:前瞻性纳入2013年1月至2017年10月于中山大学附属第六医院诊断为慢性放射性肠炎的57例患者作为慢性放射性肠炎组,其中放射性小肠炎18例,放射性直肠炎39例。同时选取同期57例健康体检者作为正常对照组。收集受试者的一般资料,评估其营养状况,采用人体成分分析仪检测各种人体成分。比较慢性放射性肠炎和正常对照组人体成分的差异,以及放射性小肠炎和直肠炎之间人体成分的差异。结果:慢性放射性肠炎患者发生营养风险和营养不良的比例均高于正常对照组(均P<0.05)。放射性小肠炎患者细胞内液[(15.42±2.21)L比(17.14±2.21)L]、总液量[(24.75±3.69)L比(27.14±3.08)L]、外液比值(0.37±0.01比0.35±0.02)、蛋白总量[(7.54±1.45)kg比(8.53±1.75)kg]、脂肪总量[(9.72±4.53)kg比(15.15±5.86)kg]、瘦组织[(34.59±4.95)kg比(38.12±4.40)kg]、手臂肌肉围度[(19.52±1.40)kg比(21.06±2.00)kg]、体质量指数[(19.39±3.51)kg比(20.50±3.10)kg]均显著低于放射性直肠炎患者,差异均具有统计学意义(均P<0.05)。结论:人体成分分析可以提供简便和准确的人体测量,适用于评估慢性放射性肠炎患者的营养状态。

Objective To evaluate the nutritional status of patients with chronic radiation-induced intestinal injury by using the body composition analysis and to explore the clinical application value.Methods A group of 57 patients diagnosed as chronic radiation-induced intestinal injury in the Sixth Affiliated Hospital of Sun Yat-sen University from January 2013 to October 2017 were enrolled prospectively as chronic radiation-induced intestinal injury group,including 18 patients with radiation enteritis and 39 with radiation proctitis.And 57 healthy people were enrolled as the normal control group at the same time.The general data of the chronic radiation-induced intestinal injury group and normal control group were collected and the nutritional status was evaluated.The body compositions were detected by body composition analyzer.The differences in body composition between the chronic radiation-induced intestinal injury group and the normal control group were analyzed and the differences between radiation enteritis and radiation proctitis patients were analyzed as well.Results Compared with the normal control group,the ratios of nutrition risk and malnutrition in chronic radiation-induced intestinal injury group were higher(all P<0.05).The body composition analysis results showed that the intracellular fluid[(15.42±2.21)L vs(17.14±2.21)L],total fluid[(24.75±3.69)L vs(27.14±3.08)L],ratio of extracellular fluid(0.37±0.01 vs 0.35±0.02),total protein content[(7.54±1.45)kg vs(8.53±1.75)kg],total fat content[(9.72±4.53)kg vs(15.15±5.86)kg],lean body mass[(34.59±4.95)kg vs(38.12±4.40)kg],AMC[(19.52±1.40)kg vs(21.06±2.00)kg],BMI[(19.39±3.51)kg vs(20.50±3.10)kg]were lower in radiation enteritis group as compared with radiation proctitis group(all P<0.05).Conclusions The body composition analysiscan provide simple and accurate anthropometric measurements to evaluate the nutritional status of patients with chronic radiation-induced intestinal injury.