摘要
Gene regulatory networks play pivotal roles in our understanding of biological processes/mechanisms at the molecular level.Many studies have developed sample-specific or cell-type-specific gene regulatory networks from single-cell transcriptomic data based on a large amount of cell samples.Here,we review the state-of-the-art computational algorithms and describe various applications of gene regulatory networks in biological studies.
基金
supported by the National Key Research and Development Program of China(2017YFA0505500)
Strategic Priority Research Program of the Chinese Academy of Sciences(XDB38040400)
National Science Foundation of China(31771476 and 31930022)
Shanghai Municipal Science and Technology Major Project(2017SHZDZX01)。
