细胞外囊泡在糖尿病创面修复中的作用机制及应用

Mechanism and application of extracellular vesicles in diabetic wound repair

随着糖尿病发病率逐年增高,糖尿病相关创面带来的社会经济负担日益加重。尽管在过去的几十年里,可选用的治疗方案逐渐增多,开发具有良好的治疗能效的新方法、新材料,从而实现糖尿病创面尤其是难愈创面的快速、高质量修复,仍具有重大的临床意义和市场价值。细胞外囊泡(EV)在“去细胞的干细胞治疗”手段中备受关注,有望为糖尿病创面的治疗提供新方法。本文回顾其在糖尿病创面愈合中的作用,特别是对炎症反应、细胞增殖、迁移、血管生成、胶原生成和细胞外基质重构方面的影响,以期为解决糖尿病患者创面修复问题提供新的思路和方法。

As the incidence of diabetes increases year by year,the social and economic burden of diabetes-related wounds is increasing.Although the number of treatment options has been increasing in the past few decades,the development of new methods and materials with good therapeutic energy efficiency,so as to achieve rapid and high-quality repair of diabetic wounds,especially refractory wounds,is still of great clinical significance and market value.Extracellular vesicles have attracted much attention in“decellular stem cell therapy”and are expected to provide a new method for the treatment of diabetic wounds.This paper reviews its role in wound healing in diabetes,especially its effects on inflammatory response,cell proliferation,migration,angiogenesis,collagen generation and extracellular matrix remodeling,in order to provide new ideas and methods for wound healing in diabetic patients.