辅助性T淋巴细胞17在慢性炎症性肝病中的研究进展

Research advances in T helper 17 cells in chronic inflammatory liver diseases

辅助性T淋巴细胞17(Th17)由初始CD4+T淋巴细胞分化而来,可分泌IL-17、IL-21、IL-22等一系列细胞因子,同时接受许多细胞因子和基因的调节,在各种炎性疾病中发挥重要作用。Th17分布广泛,与多种系统疾病均有联系,可通过分泌促炎因子、拮抗调节性T淋巴细胞的免疫抑制作用,参与慢性炎性/自身免疫性疾病的调控。归纳和概述了近几年Th17与各种慢性炎症性肝病发病机制的相关研究,为其科研思路和临床治疗提供一定的参考。

T helper 17(Th17)cells,differentiated from nave CD4+T cells,can secrete a series of cytokines including interleukin-17,interleukin-21,and interleukin-22 and are meanwhile regulated by a variety of cytokines and genes,playing an important role in various inflammatory diseases.Th17 cells are widely distributed in vivo and are associated with diseases in many systems.They are involved in the regulation of chronic inflammatory/autoimmune diseases by secreting pro-inflammatory factors and antagonizing the immunosuppressive effect of regulatory T cells.This article reviews the recent studies on the association between Th17 cells and the pathogenesis of various chronic inflammatory liver diseases,so as to provide a reference for scientific research and clinical treatment.