肠道菌群和胆汁酸通路在非酒精性脂肪性肝病发病中的作用

Role of gut microbiota and bile acid pathway in nonalcoholic fatty liver disease

非酒精性脂肪性肝病是一组病理生理机制尚不明确的疾病,与代谢综合征密切相关。肠道菌群产生的细菌成分及代谢产物调节糖脂代谢、炎症反应及氧化应激。胆汁酸激活其受体后通过多种信号通路调节免疫功能及能量、物质代谢。肠道菌群与胆汁酸通过肠肝循环相互作用,二者结构及功能的改变参与非酒精性脂肪性肝病的发生发展。旨在综述肠道菌群、胆汁酸稳态失调及二者相互作用对非酒精性脂肪性肝病的影响。

Nonalcoholic fatty liver disease is a group of diseases with unclear pathophysiological mechanism and is closely associated with metabolic syndrome.Bacterial components and metabolites produced by gut microbiota can regulate glucose and lipid metabolism,inflammatory response,and oxidative stress,and bile acids regulate immune function,energy metabolism,and material metabolism through various signaling pathways after activating their receptors.Gut microbiota and bile acids interact with each other through enterohepatic circulation,and the changes of their structure and function are involved in the development and progression of nonalcoholic fatty liver disease.This article reviews the effect of the homeostatic dysregulation of gut microbiota and bile acids and their interactions on nonalcoholic fatty liver disease.