循环游离DNA在肝细胞癌诊断和治疗中的应用

Application of circulating free DNA in the diagnosis and treatment of hepatocellular carcinoma

肝细胞癌早期诊断率低,缺乏高敏感度和高特异度的肿瘤标志物。近年来,以循环游离DNA(cfDNA)为代表的液体活检技术已成为诊断癌症的辅助手段,由于具备无创、便捷、可重复操作等优点而备受关注。在近年来国内外相关研究的基础上,从生物学特性、检测技术、临床应用方面总结并分析了cfDNA在HCC诊断和治疗领域的研究进展,为临床提供更明确的诊疗依据。

Hepatocellular carcinoma has a low early diagnostic rate,and there is a lack of highly sensitive and specific tumor markers.In recent years,fluid biopsy technique,represented by circulating free DNA(cfDNA),has become an auxiliary method for the diagnosis of cancer and has attracted more and more attention due to its advantages of noninvasiveness,convenience,and repeatability.With reference to the recent studies in China and foreign countries,this article summarizes and analyzes the advances in cfDNA in the diagnosis and treatment of hepatocellular carcinoma from the aspects of biological characteristics,detection techniques,and clinical application,so as to provide a basis for clinical diagnosis and treatment.