抗生素软膏联合维生素B2、西咪替丁治疗小儿多发性口腔溃疡的效果

Effect of antibiotic ointment combined with vitamin B2 and cimetidine in the treatment of multiple oral ulcer in children

目的探讨抗生素软膏联合维生素B2、西咪替丁治疗小儿多发性口腔溃疡的效果。方法将80例多发性口腔溃疡患儿以单双号随机化分为对照组和观察组,各40例。对照组采用抗生素软膏进行治疗,观察组采用抗生素软膏联合维生素B2、西咪替丁进行治疗。比较两组的治疗效果。结果观察组的治疗总有效率高于对照组,治疗后3 d的MOPS评分低于对照组,疼痛消失时间、溃疡愈合时间短于对照组,溃疡个数少于对照组,溃疡面积小于对照组,溃疡复发时间间隔长于对照组(P<0.05)。治疗后,两组的CRP、TNF-α、IL-8水平及CD8+均降低,IL-2水平、CD4+、CD3+均升高,且观察组优于对照组(P<0.05)。结论抗生素软膏联合维生素B2、西咪替丁治疗小儿多发性口腔溃疡有着较高的价值。

Objective To explore the effect of antibiotic ointment combined with vitamin B2 and cimetidine in the treatment of multiple oral ulcer in children.Methods Eighty children with multiple oral ulcer were divided into control group and observation group by random grouping of single and even numbers,with 40 cases in each group.The control group was treated with antibiotic ointment,and the observation group was treated with antibiotic ointment combined with vitamin B2 and cimetidine.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment of the observation group was higher than that of the control group,the MOPS score at 3 days after treatment was lower than that of the control group,the pain relief time and ulcer healing time were shorter than those of the control group,the number of ulcers was less than that of the control group,the ulcer area was smaller than that of the control group,and the ulcer recurrence time interval was longer than that of the control group(P<0.05).After treatment,the levels of CRP,TNF-α,IL-8 and CD8+in both groups decreased,while the level of IL-2,CD4+and CD3+increased,and those of the observation group were better than the control group(P<0.05).Conclusion Antibiotic ointment combined with vitamin B2 and cimetidine has high value in the treatment of multiple oral ulcer in children.