归脾汤加味治疗肺癌初始化疗后癌因性疲乏的临床效果

Clinical effect of Guipi decoction in the treatment of cancer-related fatigue after initial chemotherapy for lung cancer

目的分析归脾汤加味治疗肺癌初始化疗后癌因性疲乏(CRF)的临床效果。方法选取42例肺癌标准含铂双药初始化疗后CRF的患者,随机分为试验组和对照组,各21例。化疗后第8~14天,试验组给予归脾汤治疗,对照组给予对症治疗。比较两组的治疗效果。结果化疗后第11、13、15天,试验组的BFI评分、改良生活质量评分及中医症状评分改善总有效率均明显优于对照组(P<0.05)。试验组的纳差、腹胀、失眠或嗜睡发生率明显低于对照组,口干发生率明显高于对照组(P<0.05)。结论与对症治疗相比,归脾汤加味治疗肺癌初始化疗后CRF具有良好的疗效和安全性。

Objective To analyze the clinical effect of Guipi decoction in the treatment of cancer-related fatigue(CRF)after initial chemotherapy for lung cancer.Methods A total of 42 cases of lung cancer patients with CRF after initial treatment with standard platinum dual-drug therapy were selected and randomly divided into experimental group and control group,with 21 cases in each group.From 8 to 14 days after chemotherapy,the experimental group was treated with Guipi decoction,and the control group was treated with symptomatic treatment.The therapeutic effects of the two groups were compared.Results On the 11th,13th and 15th days after chemotherapy,the BFI score,improved quality of life score and total effective rate of TCM symptom score improvement of the experimental group were significantly better than those of the control group(P<0.05).The incidences of anorexia,abdominal distension,insomnia or lethargy of the experimental group were significantly lower than those of the control group,and the incidence of xerostomia was significantly higher than that of the control group(P<0.05).Conclusion Compared with symptomatic treatment,Guipi decoction has a good efficacy and safety in the treatment of CRF after initial chemotherapy for lung cancer.