奥曲肽联合垂体后叶素治疗肝硬化上消化道出血的疗效观察

Effect of octreotide combined with pituitrin on upper gastrointestinal bleeding in patients with liver cirrhosis

目的:探讨应用奥曲肽联合垂体后叶素治疗肝硬化患者并发上消化道出血的效果。方法:将120例肝硬化并发上消化道出血的患者随机分为给予单用垂体后叶素治疗的对照组和给予奥曲肽联合垂体后叶素治疗的观察组,每组60例,然后将对两组患者的治疗总有效率、平均止血时间以及不良反应等情况进行比较。结果:观察组患者中,治疗的总有效率为98.33%,明显高于对照组的75.00%,组间差异有统计学意义(P<0.05);观察组患者的平均出血停止时间为明显低短对照组,两组差异有统计学意义(P<0.05)。结论:应用奥曲肽联合垂体后叶素治疗肝硬化上消化道出血的效果明显、止血迅速且安全性较高,有着重要的临床参考意义。

Objective To investigate the effect of octreotide combined with Pituitrin in the treatment of upper gastrointestinal bleeding in patients with cirrhosis.Method 120 patients with liver cirrhosis complicated with upper gastrointestinal bleeding admitted to our hospital were randomly divided into control group treated with Pituitrin alone and observation group treated with octreotide combined with pituitrin,60 cases in each group,and then the total effective rate and average of the two groups of patients were treated.Hemostatic time and adverse reactions were compared.Results In the observation group,the total effective rate was 98.33%,significantly higher than the total effective rate of 75.00%of the control group,the difference was statistically significant(P<0.05);in the observation group,the average stop time of bleeding was significantly shorter than the control group,the difference was statistically significant(P<0.05).Conclusion Octreotide combined with Pituitrin in the treatment of liver cirrhosis patients with upper gastrointestinal bleeding,the effect is obvious,hemostasis is rapid and safe,has an important clinical reference.