骨膜组织工程设计:共性与个性的结合

Designing of periosteum tissue engineering: combination of generality and individuality

背景:组织工程骨膜以其优良的成骨潜能在骨组织的损伤修复中具有广泛的应用前景。然而,如何利用骨膜制定一种最理想的骨再生策略仍待阐明。目的:从共性与个性2个角度,对骨膜的组织结构、成骨效应及应用作一综述,旨在探讨骨膜组织工程中的一些尚未阐明的问题,并由此提出新的修复策略。方法:应用PubMed、Embase、Web of Science、CNKI和万方数据库进行检索,主要的检索词为“periosteal osteogenesis;periosteum tissue engineering;PDC;PEM;periosteal structure;scaffold of periosteal tissue engineering;vascularized periosteum;骨膜成骨;骨膜组织工程;骨膜来源细胞;骨膜细胞外基质;骨膜结构;骨膜组织工程支架;血管化骨膜”,最终纳入69篇文献进行综述。结果与结论:组织工程骨膜是基于天然骨膜结构而设计的,天然骨膜中的各成分被广泛运用于骨膜组织工程。然而,目前对于骨膜的不同成分或其组合所带来的成骨潜能认知仍旧有限,如何设计最理想的组织工程骨膜也尚待阐明。在此,作者提出了一种新的骨膜修复策略,称为“共性+个性”策略,这一策略将在考虑通用性的基础上进行定制化的骨膜组织工程设计,从而更好地满足临床上对骨修复的治疗需求。如何实现共性与个性的有机结合以获得良好的临床骨修复效果,在未来骨膜组织工程的研究中具有着重要意义。

BACKGROUND: Tissue engineered periosteum has broad application prospect in bone repair for its promising osteogenic potential. However, we are facing thedilemma of taking advantage of periosteum to develop an optimal strategy for bone regeneration.OBJECTIVE: In this review, we summary the histological structure and osteogenic potential of periosteum as well as its application in tissue engineering fromthe point of view of generality and individuality, discuss some undefined issues of periosteum tissue engineering and explore perspective strategies for bonerepair.METHODS: We searched in PubMed, Embase, Web of Science, CNKI and Wanfang databases with the main keywords of “periosteal osteogenesis;periosteumtissue engineering;PDC;PEM;periosteal structure;scaffold of periosteal tissue engineering;vascularized periosteum” and 69 articles were included for thereview.RESULTS AND CONCLUSION: The designing of tissue engineered periosteum is based on the structure of natural periosteum. The components of naturalperiosteum are widely used in periosteum tissue engineering. However, limited researches on osteogenic potential of various components and theircombinations hinder our understanding and how to design the optimal tissue engineered periosteum remains to be further clarified. Here, we propose a newstrategy called “Generality and Individuality”, which customizes tissue engineered periosteum on the basis of commonality to meet the clinical needs of bonerepair better. We believe it is of great significance to reach the practically sound combination of generality and individuality and achieve the optimal curativeeffect of bone repair in the future researches.