不同来源的间充质干细胞在早期骨关节炎中治疗的特点比较及展望

Comparison and prospect of different mesenchymal stem cells in the treatment of early osteoarthritis

骨关节炎(OA)是以关节软骨退变、软骨下骨重塑、关节间隙变窄及边缘骨赘增生为主要病理改变的常见关节疾病之一。随着对OA治疗研究的不断进展,干细胞治疗骨关节炎在其前景上得到了广大的认可,间充质干细胞包括骨髓间充质干细胞、脂肪间充质干细胞、滑膜间充质干细胞、外周血间充质干细胞、脐血间充质干细胞等,不同来源的间充质干细胞在治疗骨关节炎上都有各自的特点。

Osteoarthritis(OA)is one of the common joint diseases with major pathological changes such as articular cartilage degeneration,subchondral bone remodeling,joint space narrowing and marginal osteophyte proliferation.With the continuous progress of research on OA treatment,the prospect of the stem cells has been widely recognized.Mesenchymal stem cells include bone marrow mesenchymal stem cells,adipose derived stem cell,synovial mesenchymal stem cells and peripheral blood mesenchymal stem cells,umbilical cord blood mesenchymal stem cells.Mesenchymal stem cells from different sources have their own characteristics in the treatment of osteoarthritis.