硫氧还蛋白相互作用蛋白与肥胖相关性肾小球病的研究进展

Progress in the research of thioredoxin-interacting proteins and obesity-related glomerulopathy

随着全球肥胖患病率逐渐增加,肥胖相关性肾小球病(ORG)的发病率日益增高。ORG以非肾病性蛋白尿为主要临床表现,随病情发展可进展至终末期肾病。病理表现以肾小球肥大、局灶节段肾小球硬化为特征。研究表明,ORG的发病与慢性组织低度炎症反应、氧化应激、肾素-血管紧张素-醛固酮系统激活及胰岛素抵抗等密切相关。硫氧还蛋白相互作用蛋白(Txnip)为一种多蛋白复合物,可促进氧化应激,参与多种炎症反应。本文将对Txnip与肥胖相关性肾小球病的研究进展进行综述。

The incidence of obesity-related glomerular nephropathy(ORG)is increasing,along with the increasing prevalence of obesity worldwide.Non-nephrotic proteinuria is the main clinical manifestation of ORG;ORG eventually progresses to end-stage renal disease.The pathological manifestations are characterized by glomerular hypertrophy or focal segmental glomerular sclerosis.Researchers have shown that the incidence of ORG is closely related to chronic inflammatory responses,oxidative stress,the activation of the renin-angiotensinaldosterone system,and insulin resistance.Thioredoxin-interacting protein(Txnip)is a major component of a multiprotein complex that promotes oxidative stress and plays an important role in a variety of inflammatory processes.This article will review the research progresses on Txnip and obesity-related glomerulopathy.