褪黑素与胰腺疾病的研究进展

Research progress of melatonin and pancreatic diseases

褪黑素是由松果体分泌的一种吲哚胺,在各种生理活动中起着关键作用,包括调节昼夜节律、免疫应答、氧化过程及细胞凋亡。近年来,褪黑素的抗肿瘤特性逐渐引起关注。大量研究发现,褪黑素在急性胰腺炎早期过程中起保护作用,可通过细胞凋亡途径抑制胰腺癌细胞的产生,且可通过自噬作用调节胰腺内分泌激素的合成分泌从而影响胰腺内分泌肿瘤的发展。由此,褪黑素可能影响胰腺疾病的发展,但其对胰腺疾病的作用机理尚未完全明确。本文综述了近几年褪黑素与胰腺疾病的研究进展,分析了褪黑素在胰腺疾病中的作用,以及褪黑素联合化疗药物对胰腺癌的治疗作用。

Melatonin is an indoleamine secreted by the pineal gland and plays a key role in a variety of physiological activities,including the regulation of circadian rhythm,immune response,oxidative process and apoptosis.In recent years,the anti-tumor properties of melatonin have attracted more and more attention.A large number of studies have found that melatonin plays a protective role in the early process of acute pancreatitis and can inhibit the production of pancreatic adenocarcinoma cells through apoptosis;moreover,it can regulate the synthesis and secretion of pancreatic endocrine hormones through autophagy and affect the development of pancreatic endocrine tumors.Therefore,melatonin may affect the development of pancreatic disease,but the mechanism of its action on pancreatic diseases has not been fully understood.This paper reviews the research progress of melatonin and pancreatic diseases in recent years,analyzes the role of melatonin in pancreatic diseases and the therapeutic effect of melatonin combined with chemotherapy drugs on pancreatic cancer.