力学调控长链非编码RNA对间充质干细胞成骨分化作用的研究进展

Research Advances in the Effect of Mechanical Regulation of Long-Chain Non-Coding RNAs on Osteogenic Differentiation of Mesenchymal Stem Cells

随着第3代高通量测序技术和组织工程的发展,近年来研究发现,许多长链非编码RNA(long-chain noncoding RNAs,LncRNAs)在力学调节间充质干细胞(mesenchymal stem cells,MSCs)的成骨分化中起重要作用。力学因素调控相关的LncRNAs,然后LncRNAs通过转录、转录后以及表观遗传等多层次发挥调节作用,进一步调控骨相关细胞功能。LncRNAs也可能作为力学响应分子参与MSCs成骨分化、骨重建以及骨骼系统疾病的病理过程。

With the development of the 3 rd-generation high-throughput sequencing technology and tissue engineering,recent studies show that many long-chain non-coding RNAs( LncRNAs) have played an important role in osteogenic differentiation of mesenchymal stem cells( MSCs).LncRNAs,which are involved in the regulation of mechanical regulation,further regulate bone-related cell functions and play a regulatory role at multiple levels,including transcription,post-transcriptional and epigenetic.LncRNAs may be involved in the osteogenic differentiation and bone remodeling of MSCs,the regulation of bone-related cell functions as a mechanical response molecule,as well as the pathological process of skeletal diseases.