神经节苷脂联合奥拉西坦治疗不同年龄段急性脑梗死认知功能障碍的疗效比较

Efficacy of Ganglioside Combined with Oxiracetam in the Treatment of Cognitive Impairment in Patients with Acute Cerebral Infarction at Different Ages

目的:比较神经节苷脂联合奥拉西坦治疗不同年龄段急性脑梗死认知功能障碍患者的临床疗效。方法:回顾性分析2017年5月—2019年6月于我院治疗的100例急性脑梗死认知功能障碍患者的临床资料,根据患者年龄分为低龄组与高龄组,每组50例。两组均给予常规治疗,并加用神经节苷脂及奥拉西坦,治疗时间均为14 d,比较两组临床疗效、认知功能、日常生活活动能力、神经功能及不良事件发生情况。结果:治疗14 d后,低龄组的临床疗效明显高于高龄组;两组MMSE及ADL评分均高于治疗前,且低龄组高于高龄组;两组NIHSS评分均低于治疗前,且低龄组低于高龄组;低龄组不良事件发生率低于高龄组,差异均有统计学意义(P<0.05)。结论:神经节苷脂联合奥拉西坦可有效改善不同年龄段急性脑梗死认知功能障碍患者的认知功能状态及神经功能,提高患者日常生活能力,具有较好的临床疗效,且对低龄患者的疗效更好,不良事件发生率更低,值得临床推广。

Objective:To investigate the clinical efficacy of ganglioside combined with oxiracetam in the treatment of cognitive impairment in patients with acute cerebral infarction of different ages.Methods:The clinical data of 100 patients with cognitive impairment of acute cerebral infarction treated in our hospital from May 2017 to June 2019 were retrospectively analyzed.According to the age of the patients,they were divided into the younger group and the older group,with 50 cases in each group.The two groups were given conventional treatment,plus ganglioside and oxiracetam.The treatment time was 14 days.The clinical efficacy,cognitive function,activities of daily living,neurological function and adverse events were compared between the two groups.Results:After 14 days of treatment,the clinical efficacy of the young group was significantly higher than that of the elderly group;the MMSE and ADL scores of the two groups were higher than those before treatment,and the younger group was higher;the NIHSS scores of the two groups were lower than those before treatment,and the younger group was lower;the incidence of adverse events in the younger group was lower than that in the elderly group,the differences were statistically significant(P<0.05).Conclusion:Ganglioside combined with oxiracetam can effectively improve the cognitive function and neurological function of patients with cognitive impairment of acute cerebral infarction of different ages,and improve the ability of daily living of patients.It has good clinical efficacy,and the curative effect of young patients is better,and the incidence of adverse events is lower,which is worthy of clinical promotion.