茵桅黄颗粒联合四磨汤口服液对足月新生儿黄疸的疗效研究

Study on Therapeutic Effect of Yinzhihuang Granule Combined with Simotang Oral Liquid on Jaundice in Full-term Newborns

目的:探讨茵桅黄颗粒联合四磨汤口服液对足月新生儿黄疸的疗效。方法:选取2018年6月—2019年12月我院收治的60例足月新生儿黄疸患儿,依据随机数表法分为2组,各30例。两组患儿均予以黄疸常规治疗,基于此,对照组加用茵栀黄颗粒,观察组于对照组基础上加用四磨汤口服液。对比两组患儿临床疗效、临床指标及治疗前、治疗3d后、治疗5d后血清胆红素值以及不良反应发生情况。结果:相较对照组,观察组治疗总有效率较高,差异有统计学意义(P<0.05),黄疸消退时间、光疗时间及住院时间均较短,差异有统计学意义(P<0.05);对比两组治疗前血清胆红素水平,差异无统计学意义(P>0.05);两组患儿治疗3、5d后血清胆红素水平均下降,且观察组下降幅度较大,差异有统计学意义(P<0.05);对比两组不良反应发生率,差异无统计学意义(P>0.05)。结论:足月新生儿黄疸采用茵桅黄颗粒联合四磨汤口服液治疗效果显著,可加速黄疸消退并降低血清胆红素水平,利于患儿预后,值得临床推广。

Objective:To investigate the curative effect of Yinzhihuang granule combined with Simotang oral liquid on jaundice of fullterm neonates.Methods:60 cases of full-term neonatal jaundice in our hospital from June 2018 to December 2019 were selected and divided into two groups according to the random number table method,30 cases in each.Both groups were given routine treatment of jaundice.Based on this,the control group was supplemented with Yinzhihuang granules,and the observation group was given Simotang oral solution on the basis of the control group.The clinical efficacy,clinical indicators and pre-treatment,3d after treatment,and 5d after treatment were compared between the two groups of children.Results:Compared with the control group,the observation group had a higher effective rate of treatment,and the difference was statistically significant(P<0.05).Compared with the control group,the observation group had shorter jaundice regression time,phototherapy time,and hospitalization time,and the difference was statistically significant(P<0.05);Compared the serum bilirubin levels between the two groups before treatment,the difference was statistically significant(P>0.05);The levels of serum bilirubin in the two groups of children decreased after 3 days and 10 days of treatment,and the decrease in the group was larger,the difference was statistically significant(P<0.05);Compared the incidence of adverse reactions between the two groups,the difference was not statistically significant(P>0.05).Conclusion:Yinzhihuang granules combined with Simotang oral liquid has a significant effect on the treatment of term neonates with jaundice.It can accelerate the resolution of jaundice and reduce the level of serum bilirubin,which is conducive to the prognosis of children and is worth clinical promotion.