文拉法辛联合阿立哌唑治疗难治性抑郁症患者的效果

Effect of Venlafaxine Combined with Aripiprazole in the Treatment of Refractory Depression

目的分析文拉法辛联合阿立哌唑治疗难治性抑郁症患者的效果。方法选取2018年11月至2020年1月辽宁省精神卫生中心分院收治的82例难治性抑郁症患者,根据床号奇数偶数法分为对照组(床号偶数者)和观察组(床号奇数者),每组41例,对照组仅给予文拉法辛治疗,观察组采取文拉法辛联合阿立哌唑治疗,比较两组患者的治疗效果、认知功能及不良反应发生情况。结果观察组治疗总有效率为87.80%,对照组为56.10%,差异有统计学意义(P<0.05)。在认知功能方面,两组非持续错误数、总反应数、持续性错误数评分比较,差异均无统计学意义(P>0.05);但观察组完成分类数、正确反应数评分均高于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论文拉法辛联合阿立哌唑在难治性抑郁症患者治疗中的应用效果显著,且不良反应发生率较低。

Objective To analyze the effect of venlafaxine combined with aripiprazole on patients with refractory depression.Methods From November 2018 to January 2020,82 patients with refractory depression admitted to Liaoning Mental Health Center Branch were divided into control group(even bed number)and observation group(odd bed number),with 41 cases in each group.The control group was treated with venlafaxine only,while the observation group was treated with venlafaxine combined with aripiprazole.The therapeutic effect,cognitive function and adverse reactions of the two groups were compared.Results The total effective rate was 87.80%in the observation group and 56.10%in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the scores of non-persistent errors,total responses and persistent errors between the two groups(P<0.05).However,the scores of complete classification and correct response in the observation group were higher than those in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Application of lafaxine combined with aripiprazole in the treatment of refractory depression is effective,and the incidence of adverse reactions is low.