微波辅助无催化剂高效串联环化合成吡啶[2,3⁃d]嘧啶衍生物

Efficient Synthesis of Pyridine[2,3-d]pyrimidine Derivatives by Catalyst-free Tandem Cyclization Under Microwave Irradiation

建立了一种吡啶[2,3-d]嘧啶类化合物的高效合成方法.以α,β⁃不饱和酮类化合物和1,3-二甲基-6-氨基脲嘧啶为原料,在微波辅助无催化剂条件下,于5~15 min内高效串联环化合成了28个具有分子多样性的吡啶[2,3-d]嘧啶类化合物,其中21个化合物未见文献报道.该方法具有原料简单易得、高效绿色、成键效率高及后处理简单等优点.

This work presents a highly efficient and simple method for the synthesis of pyridine[2,3-d]pyrimidine derivatives.This method took theα,β-unsaturated ketones compounds and 1,3-dimethyl-6-amino⁃uracil as raw material,28 pyridine[2,3-d]pyrimidine derivatives were synthesized by microwave irradiation high-efficiency tandem cyclization in 5―15 min without catalyst,including 21 compounds did not see the literature.This method has the characteristics of simple and easy raw materials,high green efficiency,high bonding efficiency and simple post-treatment.