拉贝洛尔在妊娠期高血压疾病患者中的应用效果及对新生儿出生质量的影响

Application efficacy of labetalol for patients with hypertensive disorders of pregnancy and its effect on neonatal birth quality

目的探讨拉贝洛尔在妊娠期高血压疾病(HDP)中的应用效果及对新生儿出生质量的影响。方法回顾性分析80例HDP患者的临床资料,其中40例采用硫酸镁进行降压治疗(对照组),40例采用硫酸镁联合拉贝洛尔进行降压治疗(研究组)。比较两组患者治疗前后的血压水平、治疗效果及胎儿不良结局的发生率。结果治疗后两组的血压均较治疗前降低,且研究组的血压低于对照组(均P<0.05)。研究组的治疗总有效率高于对照组,剖宫产、早产儿、围产儿死亡、胎儿宫内窘迫、新生儿窒息等的发生率均低于对照组(均P<0.05)。结论与单纯使用硫酸镁比较,硫酸镁联合拉贝洛尔可更好地控制HDP患者的血压,改善患者病情及新生儿出生质量。

Objective To explore the application efficacy of labetalol for hypertensive disorders of pregnancy(HDP)and its effect on neonatal birth quality.Methods The clinical data of 80 HDP patients were analyzed retrospectively,wherein 40 cases received magnesium sulfate(control group)and 40 cases received magnesium sulfate and labetalol(study group)for antihypertensive therapy.The pre-and post-therapeutic blood pressure,therapeutic effect,and incidence rate of fetal adverse outcomes were compared between the two groups.Results After treatment,blood pressure was declined in both groups,and the study group had lower blood pressure than the control group(all P<0.05).Compared with the control group,the study group possessed a higher total effective rate,as well as lower incidence rates of cesarean section,premature infants,perinatal death,fetal intrauterine distress,and neonatal asphyxia(all P<0.05).Conclusion By comparison with magnesium sulfate alone,combined application of magnesium sulfate and labetalol can better control blood pressure of HDP patients,and improve patients′disease and neonatal birth quality.